Is Low Testosterone Genetic?

It’s quite daunting to realize that some problems we have boil down to one thing: not external causes, but genetics itself. The same goes for testosterone problems.

Testosterone is often seen as a marker of vitality, strength, and energy in men. When it drops, the changes can be hard to ignore: lower sex drive, chronic fatigue, mood changes, and more. Many men chalk it up to age or burnout. Others take steps (such as eating better, working out, sleeping more) only to see little improvement.

That’s when a different question starts to surface: what if it’s not just lifestyle? What if this was always part of the picture, something passed down rather than picked up?

If you’re someone who is struggling with "Low T" and you can’t quite figure out why (despite doing all the right things), there’s a chance the answer might be in your DNA. 

In this article, we’ll unpack the genetic connection to low testosterone and what you can do about it if the issue is something you didn’t exactly sign up for.

How Genetics Can Affect Testosterone

A huge study of over 180,000 men in the UK found something pretty eye-opening: low testosterone can run in families. Researchers looked at men with very low testosterone (under 8 nmol/L) and compared them to those with normal levels. They discovered certain patterns in their DNA, specifically, 141 tiny markers that showed up more often in men with low testosterone. Out of those, 42 stood out as being especially important.

When men had more of these specific DNA markers, they were nearly five times more likely to have low testosterone than those with fewer markers. These markers also seem to affect how certain organs tied to hormones (like the testicles, liver, and pituitary gland) function, linking them to over 150 different genes.

So, what does this mean for you?

• Low testosterone can be passed down. About 1 in 5 cases of Low T may be tied to your genes.
• In the future, DNA tests could help identify men who are at higher risk, before symptoms even show up.
• Your lifestyle still plays a big role. Things like sleep, diet, stress, and weight still have a major impact on hormone health.

In short, yes, low testosterone can be genetic. But even if it runs in your family, there are still steps you can take to protect your health.

Can You Fix Low Testosterone if It’s Genetic?

The good news is, yes, even if low testosterone is in your genes, it’s not a life sentence. While you may be more prone to it, that doesn’t mean you’re stuck with the symptoms or that there’s nothing you can do.

Many men with genetically low testosterone find real improvement through a mix of lifestyle changes and medical support. For some, consistent strength training, better sleep routines, and a nutrient-rich diet (especially foods high in zinc, vitamin D, and healthy fats) can support hormone levels naturally. These changes help your body work more efficiently, even if your baseline is lower than average.

Others may need additional help. Testosterone replacement therapy (TRT) is one option that can restore hormone levels when the body isn’t producing enough on its own. It's typically recommended after thorough testing and discussion with a doctor, especially if symptoms are affecting daily life.

With the right approach, many men are able to feel stronger, more energetic, and mentally sharper, even if they started from a disadvantage.

Take Charge of Your Testosterone Health Today

If you suspect your testosterone levels are being shaped by more than lifestyle, you’re not alone, and you’re not without options. 

At Craft Men’s Clinic, we offer in-depth hormone testing and personalized care plans designed to uncover the root of your Low T, including genetic factors. Our team helps you move from questions to clarity, with treatment strategies tailored to your goals, health, and future.

Don’t wait for symptoms to take over. Contact Craft Men’s Clinic today and take the first step toward feeling like yourself again.

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