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Injections vs Creams vs Troches: Which TRT Wins?

Injections vs Creams vs Troches: Which TRT Wins?

Medications

4 min read

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If you’re considering testosterone replacement therapy (TRT), you’ve likely come across different methods like injections, creams, and troches. Each one works differently and comes with its own set of pros and cons.

But which option delivers the best results? 

If you’re already on TRT and wondering if your current method is right for you, or if you’re just exploring your options, this article breaks down how these three types of administering testosterone work to help you make the best choice for your health and lifestyle.

What Are Injections, Creams, and Troches?

Injections, creams, and troches each work differently to deliver testosterone, and understanding how they compare can help you decide which option aligns best with your health goals and daily routine. 

Before diving into the pros and cons of each, let’s look at how these three methods work and what sets them apart:

Injections

Testosterone injections involve delivering testosterone directly into the muscle or under the skin. The injection allows testosterone to enter the bloodstream quickly, providing a steady release over time. Most people receive injections weekly or bi-weekly, depending on their prescribed dosage. 

This method is known for its consistency in maintaining testosterone levels, but it does require regular needle use, which some may find uncomfortable.

Creams

Testosterone creams are applied to the skin, usually on areas like the shoulders, arms, or abdomen. The testosterone absorbs through the skin and enters the bloodstream gradually. This method is non-invasive and easy to use, making it a convenient option for those who prefer to avoid needles. 

However, absorption can vary based on skin type, body fat, and other factors, which may affect how well the treatment works.

Troches

Troches are small lozenges that dissolve in the mouth, usually placed under the tongue or against the cheek. As they dissolve, the testosterone absorbs through the mucous membranes, entering the bloodstream directly. 

Troches offer a customizable dosage and are an alternative for those who do not want injections or creams. Some people prefer troches for their ease of use, but they may need to be taken multiple times a day to maintain stable hormone levels.

What Is the Disadvantage of Testosterone Injections?

While injections are known for their effectiveness, they also come with potential downsides:

  • Pain at the injection site, especially for those new to self-injections
  • Requires strict hygiene practices to avoid infections
  • Sharp peaks and gradual declines can cause mood swings or irritability
  • Higher testosterone levels can sometimes convert to estrogen, potentially requiring additional medication
  • Possible skin reactions at the injection site

Despite these drawbacks, many find the consistent release of testosterone worth the occasional discomfort.

Does Testosterone Cream Work as Well as Injections?

Creams are a convenient option for those who prefer to avoid needles, but they may not deliver the same consistency as injections. Here's a rundown of its pros and cons:

Pros

Easy, non-invasive application

Absorption varies based on skin type, body fat, and application site

Daily use provides a steady release of testosterone

Cons

Missed doses can lead to inconsistent hormone levels

Suitable for those with needle sensitivity

Less predictable absorption compared to injections

This can work well for men who are consistent with daily application and who have good skin absorption, but those seeking more stable and predictable levels often opt for injections.

So, Which Method of Testosterone Is Most Effective?

Effectiveness in testosterone replacement therapy depends on how well each method delivers a consistent dose. Here’s how they compare:

  • Injections:
    • Maintain stable testosterone levels over a longer period
    • Provide steady release after each dose
    • Require regular administration, typically weekly or bi-weekly
  • Creams:
    • Gradual release throughout the day
    • Convenient for those who prefer non-invasive methods
    • Absorption can vary based on skin type and application site
    • Missed doses can lead to fluctuations
  • Troches:
    • Quick absorption through mucous membranes
    • Customizable dosing
    • May require multiple doses daily to maintain balance
    • Easier to adjust doses but less consistent than injections

The most effective method often depends on individual needs, lifestyle, and how well the body absorbs each form of testosterone.

How to Decide Which Method Is Right for You

Finding the right TRT method involves more than just choosing the most effective option. It’s about what fits your lifestyle, comfort level, and daily routine.

Consider Your Routine

If you prefer a weekly or bi-weekly schedule and don’t mind needles, injections might be the easiest to manage. If daily application feels more natural to you, creams or troches could be a better fit.

Think About Comfort Level

For those uncomfortable with needles, creams and troches provide less invasive options. Creams require daily application, while troches are taken multiple times a day.

Evaluate Consistency

Injections deliver a steady dose over a longer period, making them ideal for those who prefer fewer applications. Creams and troches require more frequent dosing, which can be challenging to maintain consistently.

Assess Skin Sensitivity

Men with sensitive skin may experience irritation from creams. Troches bypass the skin and absorb through the mouth, making them a good alternative for those with skin sensitivities.

Factor in Convenience

Traveling frequently or maintaining a busy schedule might make injections more practical. Troches are easy to carry and use, while creams require dedicated application time.

Consider Your Overall Health

Existing health conditions can impact how each method affects your body. Discuss your medical history with your provider to determine the best approach.

Ready to Take the Next Step?

Finding the right TRT method starts with the right plan. Fill out our contact form today to connect with the experts at Craft Men’s Clinic and discover the best treatment option for you.

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Updated: May 22, 2025 | Published: May 22, 2025

Article written by
Anthony Dorsi
SEO Content Writer
Medically reviewed by
Dr. Bailey
Medical Advisor
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